A selection of our research publication highlights:
2023 2022 2021 2020 2019 2018
2023
Mardon K, Patel JZ, Savinainen JR, Stimson DHR, Oyagawa CRM, Grimsey NL, Migotto MA, Njiru GFM, Hamilton BR, Cowin G, Yli-Kauhaluoma J, Vanduffel W, Blakey I, Bhalla R, Cawthorne C, Celen S, Bormans G, Thurecht KJ, Ahamed M. Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β-Hydrolase Domain 6 (ABHD6). J Med Chem. 2023 Jan 12;66(1):538-552. doi: 10.1021/acs.jmedchem.2c01485. Epub 2022 Dec 14. PMID: 36516997.
Ghosh S, Fletcher NL, Huda P, Houston ZH, Howard CB, Lund ME, Lu Y, Campbell DH, Walsh BJ, Thurecht KJ. Pharmacokinetics and Biodistribution of 89Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Mol Pharm. 2023 Mar 6;20(3):1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760. Epub 2023 Jan 5. PMID: 36602058.
Chuang KH, Li Z, Huang HH, Khorasani Gerdekoohi S, Athwal D. Hemodynamic transient and functional connectivity follow structural connectivity and cell type over the brain hierarchy. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2202435120. doi: 10.1073/pnas.2202435120. Epub 2023 Jan 24. PMID: 36693103.
Jia X, Chin YK, Zhang AH, Crawford T, Zhu Y, Fletcher NL, Zhou Z, Hamilton BR, Stroet M, Thurecht KJ, Mobli M. Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation. Commun Chem. 2023 Mar 4;6(1):48. doi: 10.1038/s42004-023-00841-5.
Janjua TI, Cao Y, Ahmed-Cox A, Raza A, Moniruzzaman M, Akhter DT, Fletcher NL, Kavallaris M, Thurecht KJ, Popat A. Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma. J Control Release. 2023 Mar 23:S0168-3659(23)00207-9. doi: 10.1016/j.jconrel.2023.03.040. Epub ahead of print. PMID: 36965857.
To XV, Vegh V, Owusu-Amoah N, Cumming P, Nasrallah FA. Hippocampal demyelination is associated with increased magnetic susceptibility in a mouse model of concussion. Exp Neurol. 2023 Apr 14;365:114406. doi: 10.1016/j.expneurol.2023.114406. Epub ahead of print.
Hodono S, Rideaux R, van Kerkoerle T , Cloos MA. Initial experiences with Direct Imaging of Neuronal Activity (DIANA) in humans Arxiv [Preprint] arXiv:2303.00161v1 doi: 10.48550/arXiv.2303.00161
Kumar A, Naz F, Luthra S, Vashistha R, Kumar V, Garza-Reyes JA, Chhabra D. Digging DEEP: Futuristic building blocks of omni-channel healthcare supply chains resiliency using machine learning approach. Journal of Business Research, Volume 162, 2023, 113903, https://doi.org/10.1016/j.jbusres.2023.113903.
Bollmann S, Renton A, Dao T, Johnstone T, Civier O, Sullivan R, White D, Lyons P, Slade B, Abbott D, Amos T, Bollmann S, Botting A, Campbell M, Chang J, Close T, Eckstein K, Egan G, Evas S, Flandin G, Garner K, Garrido M, Ghosh S, Grignard M, Hannan A, Huber LR, Kaczmarzyk J, Kasper L, Kuhlmann L, Lou K, Mantilla-Ramos YJ, Mattingley J, Morris J, Narayanan A, Pestilli F, Puce A, Ribeiro F, Rogasch N, Rorden C, Schira M, Shaw T, Sowman P, Spitz G, Stewart A, Ye X, Zhu J, Hughes M, Narayanan A. Neurodesk: An accessible, flexible, and portable data analysis environment for reproducible neuroimaging. Res Sq [Preprint]. 2023 Mar 13:rs.3.rs-2649734. doi: 10.21203/rs.3.rs-2649734/v1. PMID: 36993557; PMCID: PMC10055538.
Chen M, Tieng QM, Du J, Edwards SR, Maskey D, Peshtenski E, and Reutens DC (2023). Effects of C1-INH treatment on neurobehavioral sequelae and late seizures after traumatic brain injury in a mouse model of controlled cortical impact. Neurotrauma Reports 4 (1) 124-136. doi:10.1089/neur.2022.0011
Chu W, Houston ZH, Fletcher NL, Huda P, Ahamed M, Lim TX, Day BW, Pinkham M, Thurecht KJ. Development and Validation of a Targeted Treatment for Brain Tumors Using a Multi-Drug Loaded, Relapse-Resistant Polymeric Theranostic. Biomacromolecules. 2023 May 4. doi: 10.1021/acs.biomac.3c00138. Epub ahead of print. PMID: 37143361.
Moles E, Howard CB, Huda P, Karsa M, McCalmont H, Kimpton K, Duly A, Chen Y, Huang Y, Tursky ML, Ma D, Bustamante S, Pickford R, Connerty P, Omari S, Jolly CJ, Joshi S, Shen S, Pimanda JE, Dolnikov A, Cheung LC, Kotecha RS, Norris MD, Haber M, de Bock CE, Somers K, Lock RB, Thurecht KJ, Kavallaris M. Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Sci Transl Med. 2023 May 17;15(696):eabm1262. doi: 10.1126/scitranslmed.abm1262. Epub 2023 May 17. PMID: 37196067.
Janjua TI, Cao Y, Ahmed-Cox A, Raza A, Moniruzzaman M, Akhter DT, Fletcher NL, Kavallaris M, Thurecht KJ, Popat A. Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma. J Control Release. 2023 May;357:161-174. doi: 10.1016/j.jconrel.2023.03.040. Epub 2023 Mar 30. PMID: 36965857.
Ardana A, Ghosh S, Huda P, Fletcher NL, Thurecht KJ, Williams CC. RAFT Polymer-Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo. Mol Pharm. 2023 Jun 5;20(6):3073-3087. doi: 10.1021/acs.molpharmaceut.3c00085. Epub 2023 May 23. PMID: 37218930; PMCID: PMC10245379.
Agrez M, Rybchyn MS, De Silva WGM, Mason RS, Chandler C, Piva TJ, Thurecht K, Fletcher N, Liu F, Subramaniam G, Howard CB, Blyth B, Parker S, Turner D, Rzepecka J, Knox G, Nika A, Hall A, Gooding H, Gallagher L. An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage. Sci Rep. 2023 Jul 20;13(1):11702. doi: 10.1038/s41598-023-38890-4.
2022
Agrez M, Rzepecka J, Turner D, Knox G, Chandler C, Howard CB, Fletcher N, Thurecht K, Parker S, Gooding H, Gallagher L. A novel lipidic peptide with potential to promote balanced effector-regulatory T cell responses. Sci Rep. 2022 Jul 1;12(1):11185. doi: 10.1038/s41598-022-15455-5.
Chang J, Steyn F, Ngo S, Henderson R, Guo C, Bollmann S, Fripp J, Barth M and Shaw T (2022). Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T. Journal of Open Source Software 7 (76) 4368. doi: 10.21105/joss.04368
Nguyen VT, Bollmann S, Bermingham M, Dargusch MS. (2022). Efficient modelling of permanent magnet field distribution for deep learning applications. Journal of Magnetism and Magnetic Materials 559 169521 169521. doi: 10.1016/j.jmmm.2022.169521
Gao Y, Xiong Z, Fazlollahi A, Nestor PJ, Vegh V, Nasrallah F, Winter C, Pike GB, Crozier S, Liu F, Sun H. Instant tissue field and magnetic susceptibility mapping from MRI raw phase using Laplacian enhanced deep neural networks. Neuroimage. 2022 Jun 23:119410. doi: 10.1016/j.neuroimage.2022.119410. Epub ahead of print.
Fletcher NL, Prior A, Choy O, Humphries J, Huda P, Ghosh S, Houston ZH, Bell CA, Thurecht KJ. Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chem Commun (Camb). 2022 Jun 21. doi: 10.1039/d2cc02443h. Epub ahead of print.
Zhao Y, Liu T, Ardana A, Fletcher NL, Houston ZH, Blakey I, Thurecht KJ. Investigation of a Dual siRNA/Chemotherapy Delivery System for Breast Cancer Therapy. ACS Omega. 2022 May 10;7(20):17119-17127. doi: 10.1021/acsomega.2c00620.Moinian S, Vegh V, Reutens D (2022) Towards automated in vivo parcellation of the human cerebral cortex using supervised classification of magnetic resonance fingerprinting residuals. Cerebral Cortex. Apr 28:bhac155. doi: 10.1093/cercor/bhac155. Epub ahead of print.
Sharapov D and MacAulay S (2022) Design as an Isolating Mechanism for Capturing Value from Innovation: From Cloaks and Traps to Sabotage. Academy of Management Review VOL. 47, NO. 1 doi: 10.5465/amr.2018.0413
Moinian S, Vegh V, Reutens D (2022) Towards automated in vivo parcellation of the human cerebral cortex using supervised classification of magnetic resonance fingerprinting residuals. Cerebral Cortex. Apr 28:bhac155. doi: 10.1093/cercor/bhac155. Epub ahead of print.
Shokraei Fard A, Reutens DC, Vegh V (2022) From CNNs to GANs for cross-modality medical image estimation doi: 10.1016/j.compbiomed.2022.105556
Ghosh S, Huda P, Fletcher NL, Howard CB, Walsh B, Campbell D, Pinkham MB, Thurecht KJ. (2022) Antibody-Based Formats to Target Glioblastoma: Overcoming Barriers to Protein Drug Delivery. Mol Pharmaceutics May 2;19(5):1233-1247. doi: 10.1021/acs.molpharmaceut.1c00996
Mills JA, Liu F, Jarrett TR, Fletcher NL, Thurecht KJ. Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation. Biomater Sci. 2022 Jun 14;10(12):3029-3053. doi: 10.1039/d2bm00181k.
Janowicz PW, Houston ZH, Bunt J, Fletcher NL, Bell CA, Cowin G, Howard CB, Taslima D, Westra van Holthe N, Prior A, Soh V, Ghosh S, Humphries J, Huda P, Mahler SM, Richards LJ, Thurecht KJ. Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials. 2022 Feb 17;283:121416. doi: 10.1016/j.biomaterials.2022.121416. Online ahead of print.
Su J, Pellicer-Guridi R, Edwards T, Fuentes M, Rosen MS, Vegh V, Reutens D. A CNN based software gradiometer for electromagnetic background noise reduction in low field MRI applications. IEEE Trans Med Imaging. 2022 vol. 41, no. 5, pp. 1007-1016, May 2022, doi: 10.1109/TMI.2022.3147450.
Ghosh S, Huda P, Fletcher NL, Campbell D, Thurecht KJ, Walsh B (2022) Clinical development of an anti-GPC-1 antibody for the treatment of cancer, Expert Opinion on Biological Therapy, 22:5, 603-613, doi: 10.1080/14712598.2022.2033204
Ahfock D, Pyne S, and McLachlan GJ (2022). Statistical file-matching of non-Gaussian data: a game theoretic approach. Computational Statistics and Data Analysis 168, Article, 107387.
Yang Q, Reutens DC, Vegh V. Generalisation of continuous time random walk to anomalous diffusion MRI models with an age-related evaluation of human corpus callosum. Neuroimage. 2022 Jan 13:118903. doi: 10.1016/j.neuroimage.2022.118903. Epub ahead of print.
2021
Moinian S, Vegh V, O'Brien K, Reutens D. Magnetic resonance fingerprinting residual signals can disassociate human grey matter regions. Brain Struct Funct. 2022 Jan;227(1):313-329. doi: 10.1007/s00429-021-02402-9. Epub 2021 Oct 25.
Stewart AW, Robinson SD, O’Brien K, Jin J, Widhalm G, Hangel G, Walls A, Goodwin J, Eckstein K, Tourell M, Morgan C, Narayanan A, Barth M, Bollmann S. QSMxT: Robust masking and artifact reduction for quantitative susceptibility mapping. Magn Reson Med. 2021 Oct 22. doi: 10.1002/mrm.29048. Online ahead of print.
Lim TX, Pierens GK, Bernhardt PV, Ahamed M, Reutens DC. Synthesis, isolation and characterisation of fluorinated-benzimidazoisoquinoline regioisomers. Magn Reson Chem. 2021 Jul 11. doi: 10.1002/mrc.5193. Online ahead of print.
Vegh V, Moinian S, Yang Q, Reutens D. Fractional order magnetic resonance fingerprinting in the human cerebral cortex. Mathematics. 2021 June 28.
Cognolato F, O'Brien K, Jin J, Robinson S, Laun FB, Barth M, Bollmann S NeXtQSM--A complete deep learning pipeline for data-consistent quantitative susceptibility mapping trained with hybrid data arXiv preprint arXiv:2107.07752
Taylor LS, Bergström CAS, Lavasanifar A, Qian F, Suryanarayanan R, and Thurecht KJ Celebrating Women in the Pharmaceutical Sciences Mol. Pharmaceutics 2021, 18, 4, 1487–1490 doi: 10.1021/acs.molpharmaceut.0c01197
Pregelj L, Hine DC, Kesselheim AS, Darrow JJ. Assessing the Impact of FDA Breakthrough Therapy Designation Timing on Trial Characteristics and Development Speed Clin Pharmacol Ther. 2021 110(4):1018-1024. doi: 10.1002/cpt.2318. Epub 2021 Jul 1.
Lim TX, Ahamed M, Reutens DC. The aryl hydrocarbon receptor: A diagnostic and therapeutic target in glioma. Drug Discov Today. 2021 Oct 6;S1359-6446(21)00427-X. doi: 10.1016/j.drudis.2021.09.021. Online ahead of print.
Chandra J, Teoh SM, Kuo P, Tolley L, Bashaw AA, Tuong ZK, Liu Y, Chen Z, Wells JW, Yu C, Frazer IH, Yu M. Manganese-Doped Silica-Based Nanoparticles Promote the Efficacy of Antigen-Specific Immunotherapy. J Immunol. 2021 Mar 1;206(5):987-998. doi: 10.4049/jimmunol.2000355. Epub 2021 Jan 27.
Farzammehr MA, Mohammadzadeh M, Zadkarami MR, and McLachlan GJ (2021). Bayesian analysis of generalized linear mixed models with spatial correlated and unrestricted skew normal errors. Communications in Statistics - Theory and Methods. doi: 10.1080/03610926.2021.1897843
Tieng QM, Su J, Vegh V, and Reutens, DC (2021). Efficient solution of linear inverse problems using an iterative linear neural network with a generalization training approach. Journal of Physics Communications 5 (3) 035008 035008.
Chandra J, Woo WP, Finlayson N, Liu HY, McGrath M, Ladwa R, Brauer M, Xu Y, Hanson S, Panizza B, Frazer IH, Porceddu SV. A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC). Cancer Immunol Immunother. 2021 Mar;70(3):743-753. doi: 10.1007/s00262-020-02720-7
2020
Abbasi-Rad S, O'Brien K, Kelly S, Vegh V, Rodell A, Tesiram Y, Jin J, Barth M, Bollmann S. Improving FLAIR SAR Efficiency at 7T by Adaptive Tailoring of Adiabatic Pulse Power through Deep Learning Estimation. Magnetic Resonance in Medicine Magn Reson Med. 2020 Nov 23. doi: 10.1002/mrm.28590.
Fletcher NL, Kempe K, and Thurecht KJ. (2020). Next‐generation polymeric nanomedicines for oncology: perspectives and future directions. Macromolecular Rapid Communications 2000319. doi: 10.1002/marc.202000319
Gee AD., Andersson J, Bhalla R, Choe YS, Dick DW., Herth MM., Hostetler ED., Jáuregui-Haza UJ., Huang Y-Y, James ML., et al (2020). Training the next generation of radiopharmaceutical scientists. Nuclear Medicine and Biology 88-89 10-13. doi: 10.1016/j.nucmedbio.2020.06.004
Lund ME, Howard CB, Thurecht KJ, Campbell DH, Mahler SM, Walsh BJ. A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells. BMC Cancer. 2020 Dec 10;20(1):1214. doi: 10.1186/s12885-020-07562-1
Pellicer-Guridi R, Vogel MW, Vegh V, Su J, Rosen MS, Reutens DC. A numerical study of pre-polarisation switching in ultra-low field magnetic resonance imaging using dynamic permanent magnet arrays. Sci Rep. 2020 Oct 23;10(1):18141. doi: 10.1038/s41598-020-74931-y
Qiao Z, Mardon K, Stimson DHR., Migotto M-A, Reutens DC. and Bhalla R (2020). Synthesis and evaluation of 6-[18F]fluoro-3-(pyridin-3-yl)-1H-indole as potential PET tracer for targeting tryptophan 2, 3-dioxygenase (TDO). Nuclear Medicine and Biology 84-85 1-10. doi: 10.1016/j.nucmedbio.2019.12.007
Yeh MC, Tse BWC, Fletcher NL, Houston ZH, Lund M, Volpert M, Stewart C, Sokolowski KA, Jeet V, Thurecht KJ, Campbell DH, Walsh BJ, Nelson CC, Russell PJ.(2020) Targeted beta therapy of prostate cancer with 177Lu-labelled Miltuximab® antibody against glypican-1 (GPC-1). EJNMMI Res. 2020 May 7;10(1):46. doi: 10.1186/s13550-020-00637-x
Dey P, Blakey I, Stone N, Diagnostic prospects and preclinical development of optical technologies using gold nanostructure contrast agents to boost endogenous tissue contrast, Chemical Science 11 (33), 8671-8685, 2020, doi: 10.1039/D0SC01926G
Magin R, Hall MG, Karaman MM and Vegh V, Fractional calculus models of magnetic resonance phenomena: relaxation and diffusion, Critical Reviews in Biomedical Engineering, vol. 48, pp. 285-326, 2020. doi: 10.1615/critrevbiomedeng.2020033925
Thapaliya K, Vegh V, Bollmann S, Barth M, 2020. Influence of 7T GRE-MRI Signal Compartment Model Choice on Tissue Parameters. Front. Neurosci. 14. doi: 10.3389/fnins.2020.00271
Houston ZH, Bunt J, Chen K-S, Puttick S, Howard CB, Fletcher NL, Fuchs AV, Cui J, Ju Y, Cowin G, Song X, Boyd AW, Mahler SM, Richards LJ, Caruso F, Thurecht KJ (2020). Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies. ACS Central Science. doi: 10.1021/acscentsci.9b01299
Lund ME, Campbell DH, Walsh BJ. (2020) The Role of Glypican-1 in the Tumour Microenvironment. Adv Exp Med Biol. 2020;1245:163-176. doi: 10.1007/978-3-030-40146-7_8